|
CANCER BIOLOGY 101-- SYLLABUS FOR WINTER QUARTER 2018 |
|
|||
|
Two lectures per week (10:30 -11:50 AM Tu/Th in Room M114, Alway Building, School of Medicine) |
|
|||
|
One assigned discussion section (90 min TBA) per week either on Friday or Monday. Professor's office hours announced weekly (L217 inner office, 2nd Floor of Lane Building) or by appointment <lipsick@stanford.edu> Recommended textbook: Robert A Weinberg
"The Biology of Cancer" (second edition) All other readings will be available online via Canvas. |
|
|||
|
Week 1 |
Lecture 1 |
9-Jan |
Cancer Biology: The Basics |
|
|
|
Lecture 2 |
11-Jan |
Carcinogens, Retroviruses, and Oncogenes |
|
|
|
Section |
12/15-Jan |
Stehelin D, et al (1976) Nature 260: 170-3. |
|
|
Week 2 |
Lecture 3 |
16-Jan |
Tumor Clonality and Proto-Oncogene Activation |
|
|
|
Lecture 4 |
18-Jan |
Chromosomal Rearrangements and Transgenic Mice |
|
|
|
Section |
19/22-Jan |
Haupt Y, et al (1991). Cell 65: 753-63. |
|
|
Week 3 |
Lecture 5 |
23-Jan |
Tyrosine Kinases |
|
|
|
Lecture 6 |
25-Jan |
RAS Pathway |
|
|
|
Section |
26/29-Jan |
Lowenstein EJ, et al (1992) Cell 70: 431-42. |
|
|
Week 4 |
Lecture 7 |
30-Jan |
Tumor Suppressor Genes |
|
|
|
Lecture 8 |
1-Feb |
RB and Cell Cycle Control |
|
|
|
Section |
2/5-Feb |
Cavenee WK, et al (1983). Nature 305: 779-84. |
|
|
Week 5 |
Lecture 9 |
6-Feb |
P53, DNA Damage, and Cell Cycle Checkpoints |
|
|
|
Lecture 10 |
8-Feb |
Multistep Carcinogenesis |
|
|
|
Section |
9/12-Feb |
Jacks T, et al. (1994). Current Biology 4: 1-7. |
|
|
Midterm Exam (take home; problem-based) |
|
|||
|
Week 6 |
Lecture 11 |
13-Feb |
Cell Growth and Cancer |
|
|
|
Lecture 12 |
15-Feb |
Apoptosis and Cancer |
|
|
|
Section |
16/19-Feb |
Vaux DL et al (1988) Nature 335: 440-2. |
|
|
Week 7 |
Lecture 13 |
20-Feb |
Oncogenic Transcription Factors |
|
|
|
Lecture 14 |
22-Feb |
Immortality and Tumor Heterogeneity |
|
|
|
Section |
23/26-Feb |
Campbell PJ et al (2010) Nature 467: 1109-13. |
|
|
Week 8 |
Lecture 15 |
27-Feb |
Paths to Colorectal Cancer |
|
|
|
Lecture 16 |
1-Mar |
Invasion and Metastasis |
|
|
|
Section |
2/5-Mar |
Cancer Genome Atlas Network (2012) Nature 487: 330-7. |
|
|
Week 9 |
Lecture 17 |
6-Mar |
Cancer Surgery, Radiation, & Chemotherapy |
|
|
|
Lecture 18 |
8-Mar |
Hormone Therapy & Immunotherapy |
|
|
|
Section |
9/12-Mar |
Lynch TJ, et al (2004) N Engl J Med 350: 2129-39. Rizvi NA, et al (2015) Science 348:124-8. |
|
|
Week 10 |
Lecture 19 |
13-Mar |
Cancer Screening and Prevention |
|
|
|
Lecture 20 |
15-Mar |
Cancer Economics and Course Overview |
|
|
No section meeting during Week 10. Final Exam (take home; problem-based) Grading: 40% discussion section participation; 30% midterm; 30% final exam. |
||||